Brigid Gregg

The Gregg lab conducts basic and translational metabolic disease research at the Caswell Diabetes Institute. The Gregg lab is focused on characterizing early life events that predispose individuals to developing metabolic disease, with the ultimate aim of identifying interventions to improve metabolic outcomes in high risk individuals. The Gregg lab uses animal models along with biospecimens from human mother infant cohorts to study how nutritional influences in the neonatal/infancy period can have a long lasting impact on the risk of cardiometabolic diseases including obesity, insulin resistance, pancreatic beta-cell dysfunction, diabetes, and NAFLD. We are also investigators for large observational clinical study exmaining the impact of maternal blood sugar in pregnancy on human milk composition and infant metabolic risk markers. For this project the Gregg lab serves as the molecular milk analysis center and biorepository. Throughout this work we have also assessed for sex differences in offspring outcomes.